Nancy, First of all thanks for the flowers! My mother has been taking "Liquid Sinemet" for the last 3 or 4 years. The Liquid Sinemet (LS) is basically a matter of dissolving a days worth of medication with orange juice (some also add Vit. C powder) and taking a measured dose of the cocktail on a regular basis. The Sinemet pills dissolves easily in the OJ. A crude method would have you add up all the sinemet taken in a day, dissolving the pills, and take enough of the cocktail (once an hour) till , at the end of the day, you have completed the OJ. The amount of levadopa in a single dose of LS will have a much quicker result. It allows her to receive a little levadopa more often and even out her ups and downs. I have recently been talking with Brian Collins amount my mothers dosage and timing, the two critical issues. I would strongly suggest utilizing Brian's expertise and computer program concerning optimizing dosages. If you have any questions please drop me a line. Best regards Bill -- Bill Bell ([log in to unmask])