To All :- Just a few lines to thank all of you who wrote to me, both publicly and privately with advice, URLs or actual downloaded software to ebable me to compress my charts A and B into a suitably compact format for transmitting via the internet. The end result is that the BMP format for my charts (after applying PKZIP appears to be a somewhat more compact file than=A0the GIF files which I have been using before, so thanks Marjorie for the initial idea. So now, I will once more make the offer of Charts A and B, which state my explanation of why levodopa therapy gets more and more difficult to administer without under or over-dosing as the disease progresses. - The main point being that this effect owes nothing to considerations of whether or not the person started taking levodopa many years ago, or struggled for the early years on an inadequate sucession of alternative drugs. This can be of critical importance if you are trying to hold down a job while battling with Parkinson's Disease. -- Brian Collins <[log in to unmask]>