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Thomas, I take regular sinemet 25/100, 1 every 2 1/2 to 3 hrs, 1 eldepryl a day and 3 Permax (.25 each) per day. I've been taking sinemet and eldepryl since late 93 - just started Permax about 2 months ago. I'm not sure if what I'm going thru lately is the same as yours, but some of it is similar to your situation. I find that when I 1st wake up in the mornings, I actually seem to have less shuffling and freezing, but within 15 min's of waking, those symptoms do begin again. I've noticed that at mid day and night, these symptoms are more pronounced and occur much more. What can I do to help? I sit a lot at my job & at home and my theory is that these symptoms are worse when I'm sitting a lot, because they seem to lesson and go away once I get busy doing something and/or get physically active (i.e. walk, move around). Food also effects these symptoms - if I eat a big meal, lots of meat at mid-day, the "off" is worse. Hope this helps - ANYBODY got any thoughts on my "sitting too long" theory? "Mark F. Hardy" <[log in to unmask]> 44yrs/PD93 At 01:15 PM 4/22/97 -0400, you wrote: >Aan 19-4-97 22:46, in bericht <[log in to unmask]>, >Robert Thomas <[log in to unmask]> schreef: > >> I am a 50 year old with PD for four years,on meds for one and a half years, >> having big problem with end of dose wearing off and dystonia, > >Thomas, > The problem of wearing off symptoms (dystonia or dystonia+dyskinesia) are discussed elaborately the great majority of Park's don't have these reactions and in the writings about PD it doesn't get much attention. >wearing off symptoms are easily misinterpreteted as simply "off" symptoms. overmedicated. the intake of sinemet has to be equally divided over the day >