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This letter is long overdue. Just would like to let you know how Suraiya's tolcapone trial is going. She began last fall. Previous to the Tolcapone, she was having severe and frequent on/off periods, unable to get up from the sitting position. She was experiencing many bad side affects from her permax and was often depressed. The trial began with an initial dosage of 100mg of Tolcapone for the first 6 weeks. After only a week on the tolcapone, Suraiya felt AMAZING (as she puts it). She gained a lot of her energy back, was not as depressed as often and had more desire to do activities and go out. After six weeks the dosage was changed. She either received the same amount, a placebo or double the dosage (200mg). We do not know which. She has slowed down a bit since the second stage (She sometimes has a difficult on/off in the afternoon). She is notas bubbly as initially, and since we don't know the dosage there is no telling why. However, she says she fells SO MUCH better than she had felt before. She is in the third phase now, which is a repeat of the second. Her neuro assured her that once the trial is over, and the drug is approved, she will remain on the Tolcapone, which makes her very happy!! She feels the tolcapone has made a huge increase in her quality of life. She undergoes periodic half day and full day tests. Her neuro says she is doing much better, but he also doesn't know what the dosages are (the pills are pre arranged and packaged by the drug company. I will keep you up to date. Take care, Deanna