Can anyone offer me any help please. I have had PD for 11 years now, take Sinemet CR 25/100 + Lysuride (Revanil) 200mcg, 4 times a day at three and a half hour intervals. First dose of the day I also take half a Sinemet LS tablet. I suffer from the on/off fluctuations whereby I can be fine for two or three days at a time with no off periods, then I have a bad day where I can be off some or even all the day. The off periods vary a lot. Sometimes they are short lived and not too uncomfortable or disabling but sometimes they last a long time and I am VERY uncomfortable with bad muscle aches in my thighs and lower back and and very rigid all over with some tremor and I just don't know what to do with myself. I cannot lie comfortably in bed although that's where I feel I want to be. I had one of these sessions last evening and started to write to the list for help but was so uncomfortable I had to stop. So I am writing now whilst I am OK. I have to go for my regular six monthly check up with the neurologist on Tuesday 29 April and wonder, before I go, if any one has any tips. I just can't imagine how people coped before the PD medication became available. When I have these phases I just tell myself that are not permanent and I will feel better eventually. The trouble is when I am like this although I usually take a Sinemet LS to try and release me, it can take some time and sometimes doesn't work at all. I don't really want to increase my regular doseage or timings of medication as I am afraid of overdosing since I have many good days (i.e. in a 28 day period I recently recorded I had 14 days in which I had no off sessions and 14 days in which I had some off sessions of varying degrees). I realise from reading the list messages over the last 4 months or so I have been on the list that this is probably quite "normal" in those who have PD for a few years so I just wonder how others deal with it. Many thanks Best wishes to you all Susan 43/11 [log in to unmask]