On Sun 04 May, Ron Reiner wrote:
Hello Ron, I have just finished boggling at your post on Dopamine and
Addiction. I find the doctor's story very hard to believe. For a start, I
thought that the molecules that dock into the pleasure centres of the brain
are called endorphins, not Dopamine. (Or is the Doc saying that Dopamine is
generated by the action of the endorphin docking?
Secondly the Dopamine manufacturing plant which we are concered with has
all of its output dedicated to the axons which regulate the operation of our
musculature, and they do not have contact with the pleasure centres. It is
my understanding that the neuro-transmitter used in most of the brain is
acetylcholine, not dopamine.
I must admit that in the case of the levedopa which we get from our
tablets, that could I suppose wind up its journey anywhere in the brain.
However, it is still levodopa, not Dopamine, and again; the
conversion to dopamine only occurs at certain points.
And finally - and this is what really bugs me,- after 17 years of
taking levodopa I ought to have become totally=A0depressed and totally
desensitised to dopamine, and neither of these are true.=20
-- =20
Brian Collins=20
<[log in to unmask]> =20
