After having a tooth extraction, I was advised by my dentist that ibuprofin was better than aspirin or acetamenophin based painkillers, but he had no idea if these products had any interaction with sinemet or eldepryl. None are listed as dangerous on the drug side affects lists that I have. I just wondered if they perhaps had a delaying or synergic affect on my meds. Anybody notice any thing in their experience? Thanx, Ron C.