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Hi Phil,

> Question for Gray Miller or any of you other techies. Have any of
> you come across a feedback control system model of the sensing
> and muscle control elements affected by Parkinsons disease?

There *is* a system for measuring nerve impulse transmission and
obstruction ( and bl***y painful it is, too) but I think it is too crude to
be of much use in PD.  Could be wrong.  :-)    As I understand, it measures
the electrical conductivity *along* a nerve fibre. The problem with PD is a
fault in the system that converts electrical nerve signals to a chemical
messenger that jumps the synapse gap between nerve endings, and then
reproduces the electrical signal.

Apparently the only method for determining this fault at present is to
deduce, a priori, that the fault must exist because a symptom is present,
then giving a medication that *may* alleviate the symptom, and if it does,
then declaring that the fault *did* exist (reductio ad absurdum).

Gotta be a better way!!

> Just some wacky thoughts. I have these at night.

Join the club!  :-)


> Hello Phil. Yesterday I promised to find some papers about
el-stimulation.
> A good friend of mine have translated the instruction for ELPHA 2000 -
> TENS, I have such one and it helps me, if you want further information -
> please e-mail.
> Every time, and often in the middle of the night, I have cramps or pain I
> use my "ELPHA", I have had it for 2 years. the price in Danish crowns is
> about 4000,00  = $ 500,00 (about)
> Sonia

Hi Sonia,
I would be hesitant to use a TENS system with a PWP whose major PD problem
was dyskenesia (out-of-control movement), as I think that it would cause an
episode that could be difficult to control.  Perhaps with akinesia (lack of
movement) or bradykinesia (slow movement) it might be useful for pain
relief.  However, the jury is still out on whether any apparent relief is
actual or perceptual.

There is a form of physiotherapy which involves using conductive metal
plates, water, and electric current, to stimulate muscles as a form of
auto-massage.  Although the patient can control the intensity, I would be
very wary with this, also.

Jim