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> The rate of absorbtion of the tablet through the walls of the small > intestine, which is affected by how food you have eaten, and how recently ; Taking food at the same time, especially animal protein, slows the absorption of levodopa. Digestive tract problems such as diarrhoea and constipation will affect the time the tablet contents is in the small intestine, where the levodopa is absorbed. But although one can take the second and subsequent doses some 1/2 to 3/4 hour before meals, how to handle the first dose? What works for me is to drink a glass of low-fat, extra calcium milk before swallowing the Sinemet. > If you know your ED, which is one of the outputs of my notorious analysis > program (Don't worry, you won't need it for a few years yet), Would you send me a copy, please Brian? I receive MIME, and can also handle any graphic format, spreadsheet, etc. > is take Madopar 62.5 dispersible tablets as my basic unit. They are better I tried Madopar, but they appeared to provoke a dry coughing reaction. Any ideas why? > is because I have had PD for 18 years (Actually 24 years since first > symptoms). You must be doing *something* right! :-) > Well ! that's quite a lot of words, and I haven't answered your question > yet. You should know that you are asking about a subject which is far from > settled even among neurologists. General opinion seems to be that any delay in increasing levodopa dosage will lengthen the number of years it is effective. Speaking for myself, I would rather go out like a Roman Candle sooner, than sputter out like a penny candle latter. > No doubt you will have gathered that I prefer the latter approach, and yet I > don't know of any factual evidence which proves that the block-buster > approach causes any harm to the patient. My choice is based on instinct as One thing to watch is that an overdose of available dopamine within the lower digestive tract can produce moderate to severe nausea. > By the way, my charts A and B are illustrations of the same subject. If you Copy of these too, please Brian? Jim