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Hi. Artane represents a class of PD meds known as "anticholinergics" which block the transmission of acetylcholine, the chemical which induces PD symptoms when levels in the brain are insufficient to restrain the influence of this (Acetylcholine is a transmitter for a large number of nerve cell systems and only turns into the "villain" when the dopamine-acetylcholine "balancing act" is out of kilter.) In 1993 -- three years following my diagnosis -- I tried Artane for roughly a 10-day period. In my case, I experienced considerable relief from tremor and rigidity, but on the downside, I encountered a degree of mental "fuzziness" (i.e. short-term memory impairment and a general sensation of foggy thought process) and fatigue similar to how I felt after a poor night's sleep. Given the side-effects and their impact on my productivity at work, I discontinued this med. Please bear in mind that the variance in responses to meds is as broad as the manifestations of PD itself, so you shouldn't form a final conclusion on one "case history". The bottom line is that decisions concerning meds should be arrived at in consultation with a neurologist with an knowledge of PD . Hope this helps John F. 44/7