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HI P. JONES - EARLY, MONTHERAPY FOR PWP, WHO ARE UNDER 60 YRS OLD, IN WHICH TREMOR IS THE PRIMARY SYMPTOM, USUALLY CALLS FOR "ARTANE" (TRIHEXYPHENIDYL). IT IS THE MOST COMMON ANTICHOLINERGIC DRUG - WHICH WORKS BY BLOCKING THE ACTION OF ACETYLCHOLINE IN THE BRAIN. SIDE EFFECTS ARE DRY MOUTH, BLURRED VISION, NAUSEA, CONSTIPATION AND RAPID HEART BEAT. THESE LIMIT THE EFFECTIVE USE OF ARTANE. SELEGELINE (ELDEPRYL) IS MORE USEFUL AS A NEUROPROTECTOR AND THEREFORE, IS THOUGHT TO DELAY THE NEED FOR LEVODOPA THERAPY. ON THE HORIZON ARE THE COMT (CATECHOL-O-METHYL TRANSFERASE) INHIBITORS [ENTACAPONE, TOLCAPONE] NOT CURRENTLY AVAILABLE. THEY BLOCK THE ENZYME (COMT) THAT BREAKS DOWN DOPAMINE IN THE BRAIN. STEPHAN S.