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In a message dated 97-05-20 16:08:30 EDT, you write: << My Wife Doris has had PDplus for approx eight years now. In the last several months she has had periods when she cannot open her eyes. >> Go to www.ceri.com and click on the Parkinsons information line. In the interview with Annetta Freeman, she mentions the medication that helped her eyes, which were at half mast. I don't know if this will be your wife's answer. Best luck, Deanne Charlton [log in to unmask]