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Brian Collins wrote: > > and there is a quantity left over. I imagine this left-over amount as > rather like a river in flood, and over flowing its banks, spreading into > areas and stimulating muscles which we do not want to be stimulated. There > is another feature of a flooding river which is relevant: a river usually > floods at the same points, and covers the same areas of land, just as in > PD, when the dyskinesias occur, it is the same muscles which start acting > up. ( I am referring to my personal experience here: Other people will no > doubt find different muscles are affected, because (to use the flooded > river analogy, the topography of the surrounding landscape is different, so > different muscles are triggered, but again always the same for that person. > Your mention of the 'Synaptic cleft' as a return path for dopamine > interested me , because I wondered if this might be our 'flooded river' - > the place where an excess of dopamine has to go, and in the process fires > off these semi-random tremors. > Hi Brian, In your river model you forgot to mention that our body must have too some sort of "dams" and other systems for "flood control" .... what would you say abou it ? What happens if they do not operate as they should to avoid the "floods" ? :-) REgards, +----| Joao Paulo de Carvalho |------ + | [log in to unmask] | +--------| Salvador-Bahia-Brazil |------+