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On Sat 24 May, Debbie White wrote: > Is a good reaction to Permax viewed in the same way a positive reaction to > Sinemet is =97 that is, a confirmation of a PD diagnosis? My mother Joyce, 67 > and recently diagnosed, is only now feeling a positive reaction to her > drugs and it happened during her increased Permax dosages recently. She's > been on Sinemet for a few months now 25/100 about 4x/day and added Permax > about two months ago, although she is still not at her prescribed dosage. > She recently added one pill each time she took Permax and has realized > better balance, lack of dizziness, and those headaches over the eyes are > better. Also, she's sleeping well. It's had no effect on the stiffness in > her left hand and arm (nor on her slightly slurred speech, which I can > detect over the phone). Hello Debbie, I'm pleased to see that you are still in there pitching for your mom. My answer to your first question has to be 'maybe'. dopamine is=20 unique iin that it is replacing a deficiency of the same chemical in the=20 brain. The agonists like Pergolide appear in principle to be doing the same,=20 but the link is a little more tenuous As I understand your e-mail, your mum tried taking a Sinemet 25/100 with each of her Permax tablets, in addition to the 4 Sinemet which she is also taking. You don't say how many Perax per day she takes, but this is clearly quite a big rise in her dosage, and it seeme to be working! You may recall some=20 time ago, I was trying to coax your mother to increase her dosage in small steps until she noticed an improvement, but we didn't get very far: well I=20 think she is finally getting some benefit, albeit by a rather strange=20 strategy. I assume that she is now permanently on her new schedule, and feeling better? Regards, --=20 Brian Collins <[log in to unmask]>