Title: Intrastriatal taurine increases striatal extracellular dopami=
ne in
a tetrodotoxin-sensitive manner in rats.
Title Abbreviation: Neurosci Lett Date of Pub: 1996 Jul 19
Author: Ruotsalainen M; Ahtee L;
Issue/Part/Supplement: 3 Volume Pagination: 175-8
Issue: 212
MESH Headings: Animal; Corpus Striatum*; Dopamine*; Injections, Spin=
al*;
Male; Rats*; Rats, Wistar*; Support, Non-U.S. Gov't; Taurine*;
Tetrodotoxin*; 3,4-Dihydroxyphenylacetic Acid*; -PG-;
Journal Title Code: N7N Publication Type: JOURNAL ARTICLE
Date of Entry: 970106N Entry Month: 9703
Country: IRELAND Index Priority: 2
Language: Eng Unique Identifier: 96440790
Unique Identifier:
96440790 ISSN: 0304-3940
Abstract: In vivo effects of locally administered taurine on striata=
l
dopamine release and metabolism were studied by microdialysis in fre=
ely
moving rats. Concentrations of dopamine, 3,4-dihydroxyphenylacetic a=
cid
(DOPAC) and homovanillic acid (HVA) in striatal dialysates were quan=
tified
by high pressure liquid chromatography (HPLC) using electrochemical
detection. Infusion of 150 mM taurine into the striatum for 2 h indu=
ced a
2.5-fold increase in the extracellular dopamine concentration.
Extracellular DOPAC concentration increased nearly 2-fold. Taurine
infusion initially decreased HVA to 70% but afterwards increased it =
to
140% of the control. When taurine was infused simultaneously with 1 =
microM
tetrodotoxin starting 60 min after tetrodotoxin, the output of dopam=
ine
did not differ from that in the presence of tetrodotoxin alone.
Tetrodotoxin abolished the effects of taurine on dopamine metabolite=
s as
well. Tetrodotoxin-sensitivity of the effects of taurine on dopamine=
and
its metabolites suggests that intrastriatal taurine elevates extrace=
llular
dopamine by releasing it from neuronal pool.
Abstract By: Author
Address: Department of Pharmacy, University of Helsinki, Finland.
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