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P03.088 ~ b: W Gastric Myoelectrical Activi y in Patients with Parkinson's Disease: Evidence of a Primary Gastric Abnormality Richard W. McCallum, Kansas City, KS, USA, Zhiyue Lin, James P. Bennett, Charlottesville, VA, USA, Irfan Soykan, Kansas City, KS, USA. OBJECTIVE: The study aim was to investigate patterns of gastric mycelectrical activity (GMA) in patients with confirmed Parkinson's Disease (PD), both treated and untreated with L-dopa. DESIGN/METHODS: Of 11 patients aged 46 to 78 years, 5 were treated with L-dopa and had gastrointestinal symptoms and 6 were taken off L-dopa for 24 hours. GMA was measured using an ambulatory electrogastrogram (EEG) recorder (Synectics, Irving, TX). A 30-min baseline EGG recording after fasting for 6 hours or more and then a 90-min postprandial EGG recording after a standardized meal were taken. The dominant frequency, peak power (amplitude) postprandial EGG power increase, and the percentage of normal 2-4 cycles per minute (cpm) slow waves during each recording session in the two groups were computed and compared. RESULTS: Of the 6 untreated patients, 5 had a decrease in EGG power after the meal and 1 had a slight increase. Two of 5 L-dopa- treated patients had a decrease in EGG power after the meal. The postprandial EGG power increase in both untreated and treated patients was similar (mean+SEM: 3.11+1.01 vs. 1.17+1.96). Both results were abnormally decreased compared to normal subjects in our laboratory. The dominant frequency of the EGG after the meal was lower than that in the fasting state both in the untreated (3.2+0.2 vs. 3.3+0.1) and treated patients (3.1+0.1 vs. 3.2 +0.1). Tachygastria was observed in one untreated patient in the fed state and in one treated patient in the fasting state. Bradygastria was present in more than 30% of recording time in two treated patients. CONCLUSIONS: Patients with untreated PD have similar abnormalities in GMA to those with L-dopa-treated PD. This is I reflected by: a) reduced postprandial EGG power and b) decreased postprandial EGG frequency. This indicates that abnormalities in GMA in PD patients reflect direct involvement in the GI tract by the primary disease process, exacerbated by L-dopa therapy (often with accompanying upper GI symptoms.) The EGG may be useful to assess GI motility in neurodegenerative diseases. These findings are significant for PD patients because effective agents are available for treating gastric motility distur~ologic impairment. l W_ P03.088 ~ b: W Gastric Myoelectrical Activi y in Patients with Parkinson's Disease: Evidence of a Primary Gastric Abnormality Richard W. McCallum, Kansas City, KS, USA, Zhiyue Lin, James P. Bennett, Charlottesville, VA, USA, Irfan Soykan, Kansas City, KS, USA. OBJECTIVE: The study aim was to investigate patterns of gastric mycelectrical activity (GMA) in patients with confirmed Parkinson's Disease (PD), both treated and untreated with L-dopa. DESIGN/METHODS: Of 11 patients aged 46 to 78 years, 5 were treated with L-dopa and had gastrointestinal symptoms and 6 were taken off L-dopa for 24 hours. GMA was measured using an ambulatory electrogastrogram (EEG) recorder (Synectics, Irving, TX). A 30-min baseline EGG recording after fasting for 6 hours or more and then a 90-min postprandial EGG recording after a standardized meal were taken. The dominant frequency, peak power (amplitude) postprandial EGG power increase, and the percentage of normal 2-4 cycles per minute (cpm) slow waves during each recording session in the two groups were computed and compared. RESULTS: Of the 6 untreated patients, 5 had a decrease in EGG power after the meal and 1 had a slight increase. Two of 5 L-dopa- treated patients had a decrease in EGG power after the meal. The postprandial EGG power increase in both untreated and treated patients was similar (mean+SEM: 3.11+1.01 vs. 1.17+1.96). Both results were abnormally decreased compared to normal subjects in our laboratory. The dominant frequency of the EGG after the meal was lower than that in the fasting state both in the untreated (3.2+0.2 vs. 3.3+0.1) and treated patients (3.1+0.1 vs. 3.2 +0.1). Tachygastria was observed in one untreated patient in the fed state and in one treated patient in the fasting state. Bradygastria was present in more than 30% of recording time in two treated patients. CONCLUSIONS: Patients with untreated PD have similar abnormalities in GMA to those with L-dopa-treated PD. This is I reflected by: a) reduced postprandial EGG power and b) decreased postprandial EGG frequency. This indicates that abnormalities in GMA in PD patients reflect direct involvement in the GI tract by the primary disease process, exacerbated by L-dopa therapy (often with accompanying upper GI symptoms.) The EGG may be useful to assess GI motility in neurodegenerative diseases. These findings are significant for PD patients because effective agents are available for treating gastric motility distur~ologic impairment. l W_ P03.088 ~ b: W Gastric Myoelectrical Activi y in Patients with Parkinson's Disease: Evidence of a Primary Gastric Abnormality Richard W. McCallum, Kansas City, KS, USA, Zhiyue Lin, James P. Bennett, Charlottesville, VA, USA, Irfan Soykan, Kansas City, KS, USA. OBJECTIVE: The study aim was to investigate patterns of gastric mycelectrical activity (GMA) in patients with confirmed Parkinson's Disease (PD), both treated and untreated with L-dopa. DESIGN/METHODS: Of 11 patients aged 46 to 78 years, 5 were treated with L-dopa and had gastrointestinal symptoms and 6 were taken off L-dopa for 24 hours. GMA was measured using an ambulatory electrogastrogram (EEG) recorder (Synectics, Irving, TX). A 30-min baseline EGG recording after fasting for 6 hours or more and then a 90-min postprandial EGG recording after a standardized meal were taken. The dominant frequency, peak power (amplitude) postprandial EGG power increase, and the percentage of normal 2-4 cycles per minute (cpm) slow waves during each recording session in the two groups were computed and compared. RESULTS: Of the 6 untreated patients, 5 had a decrease in EGG power after the meal and 1 had a slight increase. Two of 5 L-dopa- treated patients had a decrease in EGG power after the meal. The postprandial EGG power increase in both untreated and treated patients was similar (mean+SEM: 3.11+1.01 vs. 1.17+1.96). Both results were abnormally decreased compared to normal subjects in our laboratory. The dominant frequency of the EGG after the meal was lower than that in the fasting state both in the untreated (3.2+0.2 vs. 3.3+0.1) and treated patients (3.1+0.1 vs. 3.2 +0.1). Tachygastria was observed in one untreated patient in the fed state and in one treated patient in the fasting state. Bradygastria was present in more than 30% of recording time in two treated patients. CONCLUSIONS: Patients with untreated PD have similar abnormalities in GMA to those with L-dopa-treated PD. This is I reflected by: a) reduced postprandial EGG power and b) decreased postprandial EGG frequency. This indicates that abnormalities in GMA in PD patients reflect direct involvement in the GI tract by the primary disease process, exacerbated by L-dopa therapy (often with accompanying upper GI symptoms.) The EGG may be useful to assess GI motility in neurodegenerative diseases. These findings are significant for PD patients because effective agents are available for treating gastric motility distur~ologic impairment. l W_ P03.088 ~ b: W Gastric Myoelectrical Activi y in Patients with Parkinson's Disease: Evidence of a Primary Gastric Abnormality Richard W. McCallum, Kansas City, KS, USA, Zhiyue Lin, James P. Bennett, Charlottesville, VA, USA, Irfan Soykan, Kansas City, KS, USA. OBJECTIVE: The study aim was to investigate patterns of gastric mycelectrical activity (GMA) in patients with confirmed Parkinson's Disease (PD), both treated and untreated with L-dopa. DESIGN/METHODS: Of 11 patients aged 46 to 78 years, 5 were treated with L-dopa and had gastrointestinal symptoms and 6 were taken off L-dopa for 24 hours. GMA was measured using an ambulatory electrogastrogram (EEG) recorder (Synectics, Irving, TX). A 30-min baseline EGG recording after fasting for 6 hours or more and then a 90-min postprandial EGG recording after a standardized meal were taken. The dominant frequency, peak power (amplitude) postprandial EGG power increase, and the percentage of normal 2-4 cycles per minute (cpm) slow waves during each recording session in the two groups were computed and compared. RESULTS: Of the 6 untreated patients, 5 had a decrease in EGG power after the meal and 1 had a slight increase. Two of 5 L-dopa- treated patients had a decrease in EGG power after the meal. The postprandial EGG power increase in both untreated and treated patients was similar (mean+SEM: 3.11+1.01 vs. 1.17+1.96). Both results were abnormally decreased compared to normal subjects in our laboratory. The dominant frequency of the EGG after the meal was lower than that in the fasting state both in the untreated (3.2+0.2 vs. 3.3+0.1) and treated patients (3.1+0.1 vs. 3.2 +0.1). Tachygastria was observed in one untreated patient in the fed state and in one treated patient in the fasting state. Bradygastria was present in more than 30% of recording time in two treated patients. CONCLUSIONS: Patients with untreated PD have similar abnormalities in GMA to those with L-dopa-treated PD. This is I reflected by: a) reduced postprandial EGG power and b) decreased postprandial EGG frequency. This indicates that abnormalities in GMA in PD patients reflect direct involvement in the GI tract by the primary disease process, exacerbated by L-dopa therapy (often with accompanying upper GI symptoms.) The EGG may be useful to assess GI motility in neurodegenerative diseases. These findings are significant for PD patients because effective agents are available for treating gastric motility distur~ologic impairment. l W_ P03.088 ~ b: W Gastric Myoelectrical Activi y in Patients with Parkinson's Disease: Evidence of a Primary Gastric Abnormality Richard W. McCallum, Kansas City, KS, USA, Zhiyue Lin, James P. Bennett, Charlottesville, VA, USA, Irfan Soykan, Kansas City, KS, USA. OBJECTIVE: The study aim was to investigate patterns of gastric mycelectrical activity (GMA) in patients with confirmed Parkinson's Disease (PD), both treated and untreated with L-dopa. DESIGN/METHODS: Of 11 patients aged 46 to 78 years, 5 were treated with L-dopa and had gastrointestinal symptoms and 6 were taken off L-dopa for 24 hours. GMA was measured using an ambulatory electrogastrogram (EEG) recorder (Synectics, Irving, TX). A 30-min baseline EGG recording after fasting for 6 hours or more and then a 90-min postprandial EGG recording after a standardized meal were taken. The dominant frequency, peak power (amplitude) postprandial EGG power increase, and the percentage of normal 2-4 cycles per minute (cpm) slow waves during each recording session in the two groups were computed and compared. RESULTS: Of the 6 untreated patients, 5 had a decrease in EGG power after the meal and 1 had a slight increase. Two of 5 L-dopa- treated patients had a decrease in EGG power after the meal. The postprandial EGG power increase in both untreated and treated patients was similar (mean+SEM: 3.11+1.01 vs. 1.17+1.96). Both results were abnormally decreased compared to normal subjects in our laboratory. The dominant frequency of the EGG after the meal was lower than that in the fasting state both in the untreated (3.2+0.2 vs. 3.3+0.1) and treated patients (3.1+0.1 vs. 3.2 +0.1). Tachygastria was observed in one untreated patient in the fed state and in one treated patient in the fasting state. Bradygastria was present in more than 30% of recording time in two treated patients. CONCLUSIONS: Patients with untreated PD have similar abnormalities in GMA to those with L-dopa-treated PD. This is I reflected by: a) reduced postprandial EGG power and b) decreased postprandial EGG frequency. This indicates that abnormalities in GMA in PD patients reflect direct involvement in the GI tract by the primary disease process, exacerbated by L-dopa therapy (often with accompanying upper GI symptoms.) The EGG may be useful to assess GI motility in neurodegenerative diseases. These findings are significant for PD patients because effective agents are available for treating gastric motility distur~ologic impairment. l W_ P03.088 ~ b: W Gastric Myoelectrical Activi y in Patients with Parkinson's Disease: Evidence of a Primary Gastric Abnormality Richard W. McCallum, Kansas City, KS, USA, Zhiyue Lin, James P. Bennett, Charlottesville, VA, USA, Irfan Soykan, Kansas City, KS, USA. OBJECTIVE: The study aim was to investigate patterns of gastric mycelectrical activity (GMA) in patients with confirmed Parkinson's Disease (PD), both treated and untreated with L-dopa. DESIGN/METHODS: Of 11 patients aged 46 to 78 years, 5 were treated with L-dopa and had gastrointestinal symptoms and 6 were taken off L-dopa for 24 hours. GMA was measured using an ambulatory electrogastrogram (EEG) recorder (Synectics, Irving, TX). A 30-min baseline EGG recording after fasting for 6 hours or more and then a 90-min postprandial EGG recording after a standardized meal were taken. The dominant frequency, peak power (amplitude) postprandial EGG power increase, and the percentage of normal 2-4 cycles per minute (cpm) slow waves during each recording session in the two groups were computed and compared. RESULTS: Of the 6 untreated patients, 5 had a decrease in EGG power after the meal and 1 had a slight increase. Two of 5 L-dopa- treated patients had a decrease in EGG power after the meal. The postprandial EGG power increase in both untreated and treated patients was similar (mean+SEM: 3.11+1.01 vs. 1.17+1.96). Both results were abnormally decreased compared to normal subjects in our laboratory. The dominant frequency of the EGG after the meal was lower than that in the fasting state both in the untreated (3.2+0.2 vs. 3.3+0.1) and treated patients (3.1+0.1 vs. 3.2 +0.1). Tachygastria was observed in one untreated patient in the fed state and in one treated patient in the fasting state. Bradygastria was present in more than 30% of recording time in two treated patients. CONCLUSIONS: Patients with untreated PD have similar abnormalities in GMA to those with L-dopa-treated PD. This is I reflected by: a) reduced postprandial EGG power and b) decreased postprandial EGG frequency. This indicates that abnormalities in GMA in PD patients reflect direct involvement in the GI tract by the primary disease process, exacerbated by L-dopa therapy (often with accompanying upper GI symptoms.) The EGG may be useful to assess GI motility in neurodegenerative diseases. These findings are significant for PD patients because effective agents are available for treating gastric motility distur~ologic impairment. l W_ P03.088 ~ b: W Gastric Myoelectrical Activi y in Patients with Parkinson's Disease: Evidence of a Primary Gastric Abnormality Richard W. McCallum, Kansas City, KS, USA, Zhiyue Lin, James P. Bennett, Charlottesville, VA, USA, Irfan Soykan, Kansas City, KS, USA. OBJECTIVE: The study aim was to investigate patterns of gastric mycelectrical activity (GMA) in patients with confirmed Parkinson's Disease (PD), both treated and untreated with L-dopa. DESIGN/METHODS: Of 11 patients aged 46 to 78 years, 5 were treated with L-dopa and had gastrointestinal symptoms and 6 were taken off L-dopa for 24 hours. GMA was measured using an ambulatory electrogastrogram (EEG) recorder (Synectics, Irving, TX). A 30-min baseline EGG recording after fasting for 6 hours or more and then a 90-min postprandial EGG recording after a standardized meal were taken. The dominant frequency, peak power (amplitude) postprandial EGG power increase, and the percentage of normal 2-4 cycles per minute (cpm) slow waves during each recording session in the two groups were computed and compared. RESULTS: Of the 6 untreated patients, 5 had a decrease in EGG power after the meal and 1 had a slight increase. Two of 5 L-dopa- treated patients had a decrease in EGG power after the meal. The postprandial EGG power increase in both untreated and treated patients was similar (mean+SEM: 3.11+1.01 vs. 1.17+1.96). Both results were abnormally decreased compared to normal subjects in our laboratory. The dominant frequency of the EGG after the meal was lower than that in the fasting state both in the untreated (3.2+0.2 vs. 3.3+0.1) and treated patients (3.1+0.1 vs. 3.2 +0.1). Tachygastria was observed in one untreated patient in the fed state and in one treated patient in the fasting state. Bradygastria was present in more than 30% of recording time in two treated patients. CONCLUSIONS: Patients with untreated PD have similar abnormalities in GMA to those with L-dopa-treated PD. This is I reflected by: a) reduced postprandial EGG power and b) decreased postprandial EGG frequency. This indicates that abnormalities in GMA in PD patients reflect direct involvement in the GI tract by the primary disease process, exacerbated by L-dopa therapy (often with accompanying upper GI symptoms.) The EGG may be useful to assess GI motility in neurodegenerative diseases. These findings are significant for PD patients because effective agents are available for treating gastric motility distur~ologic impairment. l W_ P03.088 ~ b: W Gastric Myoelectrical Activi y in Patients with Parkinson's Disease: Evidence of a Primary Gastric Abnormality Richard W. McCallum, Kansas City, KS, USA, Zhiyue Lin, James P. Bennett, Charlottesville, VA, USA, Irfan Soykan, Kansas City, KS, USA. OBJECTIVE: The study aim was to investigate patterns of gastric mycelectrical activity (GMA) in patients with confirmed Parkinson's Disease (PD), both treated and untreated with L-dopa. DESIGN/METHODS: Of 11 patients aged 46 to 78 years, 5 were treated with L-dopa and had gastrointestinal symptoms and 6 were taken off L-dopa for 24 hours. GMA was measured using an ambulatory electrogastrogram (EEG) recorder (Synectics, Irving, TX). A 30-min baseline EGG recording after fasting for 6 hours or more and then a 90-min postprandial EGG recording after a standardized meal were taken. The dominant frequency, peak power (amplitude) postprandial EGG power increase, and the percentage of normal 2-4 cycles per minute (cpm) slow waves during each recording session in the two groups were computed and compared. RESULTS: Of the 6 untreated patients, 5 had a decrease in EGG power after the meal and 1 had a slight increase. Two of 5 L-dopa- treated patients had a decrease in EGG power after the meal. The postprandial EGG power increase in both untreated and treated patients was similar (mean+SEM: 3.11+1.01 vs. 1.17+1.96). Both results were abnormally decreased compared to normal subjects in our laboratory. The dominant frequency of the EGG after the meal was lower than that in the fasting state both in the untreated (3.2+0.2 vs. 3.3+0.1) and treated patients (3.1+0.1 vs. 3.2 +0.1). Tachygastria was observed in one untreated patient in the fed state and in one treated patient in the fasting state. Bradygastria was present in more than 30% of recording time in two treated patients. CONCLUSIONS: Patients with untreated PD have similar abnormalities in GMA to those with L-dopa-treated PD. This is I reflected by: a) reduced postprandial EGG power and b) decreased postprandial EGG frequency. This indicates that abnormalities in GMA in PD patients reflect direct involvement in the GI tract by the primary disease process, exacerbated by L-dopa therapy (often with accompanying upper GI symptoms.) The EGG may be useful to assess GI motility in neurodegenerative diseases. These findings are significant for PD patients because effective agents are available for treating gastric motility distur~ologic impairment. l W_ P03.088 ~ b: W Gastric Myoelectrical Activi y in Patients with Parkinson's Disease: Evidence of a Primary Gastric Abnormality Richard W. McCallum, Kansas City, KS, USA, Zhiyue Lin, James P. Bennett, Charlottesville, VA, USA, Irfan Soykan, Kansas City, KS, USA. OBJECTIVE: The study aim was to investigate patterns of gastric mycelectrical activity (GMA) in patients with confirmed Parkinson's Disease (PD), both treated and untreated with L-dopa. DESIGN/METHODS: Of 11 patients aged 46 to 78 years, 5 were treated with L-dopa and had gastrointestinal symptoms and 6 were taken off L-dopa for 24 hours. GMA was measured using an ambulatory electrogastrogram (EEG) recorder (Synectics, Irving, TX). A 30-min baseline EGG recording after fasting for 6 hours or more and then a 90-min postprandial EGG recording after a standardized meal were taken. The dominant frequency, peak power (amplitude) postprandial EGG power increase, and the percentage of normal 2-4 cycles per minute (cpm) slow waves during each recording session in the two groups were computed and compared. RESULTS: Of the 6 untreated patients, 5 had a decrease in EGG power after the meal and 1 had a slight increase. Two of 5 L-dopa- treated patients had a decrease in EGG power after the meal. The postprandial EGG power increase in both untreated and treated patients was similar (mean+SEM: 3.11+1.01 vs. 1.17+1.96). Both results were abnormally decreased compared to normal subjects in our laboratory. The dominant frequency of the EGG after the meal was lower than that in the fasting state both in the untreated (3.2+0.2 vs. 3.3+0.1) and treated patients (3.1+0.1 vs. 3.2 +0.1). Tachygastria was observed in one untreated patient in the fed state and in one treated patient in the fasting state. Bradygastria was present in more than 30% of recording time in two treated patients. CONCLUSIONS: Patients with untreated PD have similar abnormalities in GMA to those with L-dopa-treated PD. This is I reflected by: a) reduced postprandial EGG power and b) decreased postprandial EGG frequency. This indicates that abnormalities in GMA in PD patients reflect direct involvement in the GI tract by the primary disease process, exacerbated by L-dopa therapy (often with accompanying upper GI symptoms.) The EGG may be useful to assess GI motility in neurodegenerative diseases. These findings are significant for PD patients because effective agents are available for treating gastric motility distur~ologic impairment. l W_ P03.088 ~ b: W Gastric Myoelectrical Activi y in Patients with Parkinson's Disease: Evidence of a Primary Gastric Abnormality Richard W. McCallum, Kansas City, KS, USA, Zhiyue Lin, James P. Bennett, Charlottesville, VA, USA, Irfan Soykan, Kansas City, KS, USA. OBJECTIVE: The study aim was to investigate patterns of gastric mycelectrical activity (GMA) in patients with confirmed Parkinson's Disease (PD), both treated and untreated with L-dopa. DESIGN/METHODS: Of 11 patients aged 46 to 78 years, 5 were treated with L-dopa and had gastrointestinal symptoms and 6 were taken off L-dopa for 24 hours. GMA was measured using an ambulatory electrogastrogram (EEG) recorder (Synectics, Irving, TX). A 30-min baseline EGG recording after fasting for 6 hours or more and then a 90-min postprandial EGG recording after a standardized meal were taken. The dominant frequency, peak power (amplitude) postprandial EGG power increase, and the percentage of normal 2-4 cycles per minute (cpm) slow waves during each recording session in the two groups were computed and compared. RESULTS: Of the 6 untreated patients, 5 had a decrease in EGG power after the meal and 1 had a slight increase. Two of 5 L-dopa- treated patients had a decrease in EGG power after the meal. The postprandial EGG power increase in both untreated and treated patients was similar (mean+SEM: 3.11+1.01 vs. 1.17+1.96). Both results were abnormally decreased compared to normal subjects in our laboratory. The dominant frequency of the EGG after the meal was lower than that in the fasting state both in the untreated (3.2+0.2 vs. 3.3+0.1) and treated patients (3.1+0.1 vs. 3.2 +0.1). Tachygastria was observed in one untreated patient in the fed state and in one treated patient in the fasting state. Bradygastria was present in more than 30% of recording time in two treated patients. CONCLUSIONS: Patients with untreated PD have similar abnormalities in GMA to those with L-dopa-treated PD. This is I reflected by: a) reduced postprandial EGG power and b) decreased postprandial EGG frequency. This indicates that abnormalities in GMA in PD patients reflect direct involvement in the GI tract by the primary disease process, exacerbated by L-dopa therapy (often with accompanying upper GI symptoms.) The EGG may be useful to assess GI motility in neurodegenerative diseases. These findings are significant for PD patients because effective agents are available for treating gastric motility distur~ologic impairment. l W_