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---------- .The latest APDA newsletter [from national office in Staten Island] states in the Fazzini column that the Sinemet instant release may be replaced with at least 2 times more levodopa in the Sinemet CR. I do not claim to be a better neurologist/pharmacist than Fazzini, but I am probably a better proofreader than average. I would guess that the 2 times more should have been 1/2 more. Will Johnston