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Hi Stephan, Just a couple thinking-out-loud comments. You cite a text that recommends crushing a Sinemet tablet and mixing it with water as a possible way to speed up absorption. If that tablet were timed release, then this method might not be suitable...possibly providing too much levodopa at a time (?) The idea of crushing the tablet reminds me of something I read this week in an earlier APDA newsletter (Spring 1996). There's a column by Enrico Fazzini, D.O., Ph.D (Asst Prof. Neurology, NY Univ.) that includes brief answers to readers questions. One reader says, in part, that it takes up to an hour for his Sinemet CR dose to start working. Fazzini replies for this specific PWP that, in part, perhaps taking a regular 25/100 Sinemet (not CR) simultaneously with the Sinemet CR would help. He always advises discussing everything with one's neurologist and he advises the neurologist be a PD specialist, not a general neuro. Has anyone's neurologist advised taking a regular Sinemet simultaneously with the Sinemet CR as a sort of boost until the Sinemet CR kicks in? Lynne CG for Virginia 78/8