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Greetings Lynne: You are correct. . . . the crush and dissolve advice does not work for Sinemet CR (see manufacturer insert). As for taking a regular Sinemet, 25/100, to "jump start" the peak dose effect, before the CR kicks in: in recent months I have consulted with two movement disorder neurologists who recommend this to their patients who complain of a delay in benefit for the CR. Also note: you can try taking the CR immediately upon waking, and waiting 30 minutes before eating and avoid protein (meat, egg whites, gelatin, beans, nuts, chocolate and pizza) for breakfast to provide the optimum condition in your stomach for absorption. Good luck. Stephan 52/6