To Anna Avery Keller-- My Jim (69/almost 1) takes Eldapril AMs and after lunch, and it does not interfere with sleep. Neuru specifically said don't take it at night, for that very reason, so if you start, ask about that. I've read some controversy, but on balance Eldapril seems now to be accepted as a legitimate neuroprotective. This listserv has been wonderful--a source of inspiration to us just learning about this disease. Camilla's CARE list is special, too. Also, thanks to all who have sent info on starting Sinemet--We will try breaking the doses down. We knew there would likely be some nausea at the start (despite the latin origins of the name Sinemet), and it's not violent, thank goodness.