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Andy, Your comments about pallidotomies certainly hold true in my case. Although I've had P. D. for 20 years tremor has never been a problen, but the dyskinesias caused by the Sinemet was driving me up the wall until I had the surgery. The pallidotomy almost entirely eliminated that. It didn't result in a miracle but I benefitted enough that my life is more pleasant. I didn't suffer any permanent ill effects although my speech was affected for a few weeks. The operation itself was most interesting and involved no pain. Joan Holliday <[log in to unmask]>