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> Jim said, " > PD is characterized by progressive loss of dopaminergic neurons in the > substantia nigra in the brain, and hypersensitising of the dopamine receptors. > > > I have never seen this reference to hypersensitising of the dopamine > receptors before. Does anyone understand what it means? I am especially > curious because of the recent research that suggests that "The increased > density of dopamine D5 receptor in peripheral blood lymphocytes may reflect > the dopaminergic hypersensitivity displayed by migraineurs and may represent > a relatively simple and reliable peripheral marker of altered dopaminergic > function. > Is this the same as the above mentioned hypersensitising of the dopamine > receptors? Hi Joan, The dopamine receptors to which I referred are those in the nerve synapse. Gee, do I give it all, and bore the ears off most, or give a little, and risk some saying, "say what?" (Sorry about that, but I have received two crits, one for being too simplistic, and the other for being too technical. :-) ) To each her/his own. Doesn't really matter much; if ya got it, ya got it. The whole process is complicated, since both chemical messengers and electrical signals are involved, with receptors and "turn-offs" and "turn-ons" for each. It doesn't help anyone to know any of this, unless they are a PD researcher! :-) If you are really interested in it all, though, let me know, and I will send you a private post. (Don't want any more crits! They do bad things to my PD. (For the techos, they produce high levels of adrenaline products, and reduce my endorphin highs.) :-) Jim