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Hello everyone, First of all I wish to thank everyone for your warm welcome. Because of your encouragement I am asking this question: What are down periods and what are up periods? How do you feel and what brings them on? I believe it pertains to medication. I am only taking Eldepryl but from what I have read most of you are taking multiple medications. Do these periods result from taking more medications than I do? Oh, so many questions, the more I read the more I have. Thanks for being there. Keep smiling, it feels good Elizabeth Wands [log in to unmask]