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I can't take sinemet, permax or parlodel because the way my body reacts to them. If I take these drugs before meals, that is when it is the worst. I all of a sudden feel my blood pressure falling off to almost nothing. Then I become terribly nausiated, and most of the time, throw up the pills and whatever else I have in my stomach. Yes, I have tried to take them after meals; doesn't seem to help much. I have also tried to build up slowly, but my system rejects any amount. And this is when I have been on one or the other. I can't imagine being on a combination. Jacob (26, dx'ed in '88)