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C Kyodo News Service

OKAYAMA, Japan, June 2 (Kyodo) Doctors at Okay ama University in western
Japan have decided to apply in July for permission to performa new type of
operation for Parkinson's disease involving implanting acapsule containing
rat cells, university officials said Monday.

The doctors, led by Takashi Omoto, professor of cerebral nerve surgery at the
Medical School at Okayama University, are planning to implant in a patient's
brain a capsule filled with rat cells which produces dopamine, an amino acid
that affects muscular coordination.

The medicaltearn willapply to the university's ethics committee for
permission forthe world's fffst such operation, the officials said.

Parkinson's disease, a neurological condition characteri~d by trembling, is
estimated to affect one in every 2,000 people in Japan. The usual treatment
is medication.

Ornoto's group believes implanting the capsule will minimize the risk
ofrejection symptoms and will prove better than medication, which has the
disadvantages of its effectiveness diminishing overtime and side effects such
as vomiting, the officials said.

In the operation, a capsule ~.l millimeter in diameter and 7 mm long, will be
implanted in the patient's brain. In experiments with a mouse and a monkey,
the rat cells were still producing dopamine one month afier the implantation
ofthe capsule, the officials said.