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Marumcia-I'm sure you'll get a lot of responses. One theory is that Protein (eaten at meal time) interfers with the uptake of dopamine in the brain and the medication is less effective when taken at meal time. Some PDs try to take their sinemet between meals, or especially on awakening with some orangjc (milk is protein). Know for sure your concern, holding his hand, feeling your warmth, the massaging are wonderful therapies for a Parkie. :-) [log in to unmask] -caregiver for MEl 75/11 (75 years old, parkinson for eleven years)