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To: Brian Collins Subject: End of dose Dynskinesias I would like to resurrect this subject which was discussed several days ago I practice what you describe as " overdosing" by taking 2 CR-Sinemets first thing in the morning, then maintaining that level throughout the useful par t of my day. I usually take 2 50-200 at 7:00 AM, 1/2 25- 100 and 1 50-200 at 11:00 AM then same again at 3:00 PM. This usually keeps me in good working order through the lunch period, however, by 1:30 I am sensitive to stressful situations and by NLT 3:30 I will have a period of dyskinesias before my 3:00 PM dose of medicine kicks in. By 7:00 PM the Sinemet wears off and I usually go through the period of dyskinesias you describe at the end of medication. What I cannot explain is the period of dyskinesias that I go through with my first dose in the morning. If I take(2) 50-200 Crs at 7:00 AM, I will have a period of dyskinesias starting at about 8:00 until about 8:45. Then by 9:00 AM it will take effect and I will be fine for the rest of my normal day. I'm sure that I am not unique in experiencing this although I do not recall seeing any discussion about it. Regards John Davis