Bruce, m'friend, I'm sure you're going to be flooded with responses to your post, but I felt a strong need to let you know I'm thinking of ya and I care. I've always found cutting back a bit on the drugs helped me rather than adding more to my daily regimen. After many years of walking that tightrope, neither worked and I was just feeling rotten all the time. That's when I opted for a pallidotomy, and THAT made a significant improvement in my life! (Not a cure, mind you, but still very beneficial!) Hang in there, m'dear.. There are some terrific new drugs in the pipeline right now which might offer you tremendous relief. Barb Mallut [log in to unmask] [log in to unmask] -----Original Message----- From: Parkinson's Information Exchange On Behalf Of B.Bruce Anderson Sent: Monday, June 09, 1997 9:37 AM To: Multiple recipients of list PARKINSN Subject: I am in need of some suggestions I have an appointment with my neurologist tomorrow morning and need some help before I see him. I have been a member of this List for almost two years now. I'm afraid I haven't paid a lot of attention to all the postings concerning medications because my PD symptoms weren't that bad, except for my speech, handwriting, some fatigue and loss of balance. Initially, I had some left side resting tremors, but they stopped almost immediately when I started on the first 3 drugs mentioned below about 2 1/2 years ago. In the past couple of weeks, though, my bradykeneisia, I believe it's called, has become severe. For the first time since about a week after I was first diagnosed I am starting to get depressed about the speed my PD is developing. My shuffling, hunched over, lurching walk is much worse and is becoming difficult to live with. My feet just freeze to the ground for about 5 seconds unless I really concentrate on not doing that. I've almost fallen down the stairs a number of times and I am concerned what will happen next time I get a work assignment. My feet now hurt constantly, probably from my hunched over posture and lurching walk. That prevents me from exercising. I take Selegiline(Eldypryl) 5mg 2x/day, Amantadine 100 mg 2x/day, Sinement 25/100 3x/day, Pergolide(Permax) .25mg 2 of them 3x/day, and Amitriptylin 25 mg 1x/day. I also take all the recommended vitamins, minerals, antioxidants and DHEA. In the past I have gone a full day with no change in my symptoms, but the symptoms weren't that bad. About a week ago I started taking 4 of the Sinements and 8 of the Pergolides instead of 3 and 6. No change. I started taking the meds between meals instead of at them. No change. Is there anything else I can do or suggest to my neuro tomorrow??. I just never get any relief. I have been tempted to stop taking everything again to see what happens, but I am afraid I will get the same result as last time Thanks in advance for any suggestions - or comments.