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Dear Wegobill: 9 June 97 Please understand, I'm not a medical professional and therefore can't give any medical advice. What I do is scan the current scientific literature (or textbooks) for interesting items that I can pass on to the Parkinsn e-mail list. Before taking any responsive action, you should consult your doctor for his advice. Zolpidem (Ambien) is a soporific (sleep promoter) as you have discovered. My report was about some Italian doctors who quite by accident found that it also relieved one single patient's PD symptoms. These "anecdotal" reports are a long way from assurance that the drug or treatment will work for anyone else. If Ambien doesn't relieve your patient's PD symptoms, I certainly would not increase the dose, as it probably will only make her more sleepy. Anything like this is worth a cautious try, as your doctor told you. But if it doesn't work, then return to the proven treatment that your doctor has set up. Cheers, Joe J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks CA 91403