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Hello , my name is Nigel Harland, aged 42, diagnosed in 1989, it was interesting to read your comments and queries, as your medication regime is virtually the same as mine, with the differnce being that I take madopar as opposed to sinemet. I can only echo some of the responses that you already received.i.e take your meds, (especially the sinemet) on an empty stomach and wait for them to take effect before eating ( half an hour to three quarters of an hour in my case). I have also found that if I take madopar at the same time as the pergolide, it does not work nearly so well , so I take madopar on its own, wait for it to "kick-in" then take the other meds. At my last meeting with my neuro, I mentioned that after adding amitriptylene to my meds list (to help me sleep) I noticed a definite improvement in my overall mobility as well, and I asked if it was feasible to increase the dose. He said it was more appropriate to add another anti depressant, Benzhexol. So I did this , and yet again there was noticeable improvement in overall mobility. Hope that this has been of use. Changing the topic, I found that eating cheese (esp' Pizzas) the previous day, completely wrecks the effectiveness of the madopar on the following morning. Best wishes [log in to unmask] ---------- > I have an appointment with my neurologist tomorrow morning and need some > help before I see him. > > I have been a member of this List for almost two years now. I'm afraid I > haven't paid a lot of attention to all the postings concerning medications > because my PD symptoms weren't that bad, except for my speech, handwriting, > some fatigue and loss of balance. Initially, I had some left side resting > tremors, but they stopped almost immediately when I started on the first 3 > drugs mentioned below about 2 1/2 years ago. In the past couple of weeks, > though, my bradykeneisia, I believe it's called, has become severe. For > the first time since about a week after I was first diagnosed I am starting > to get depressed about the speed my PD is developing. My shuffling, > hunched over, lurching walk is much worse and is becoming difficult to live > with. My feet just freeze to the ground for about 5 seconds unless I > really concentrate on not doing that. I've almost fallen down the stairs > a number of times and I am concerned what will happen next time I get a > work assignment. My feet now hurt constantly, probably from my hunched > over posture and lurching walk. That prevents me from exercising. > > I take Selegiline(Eldypryl) 5mg 2x/day, Amantadine 100 mg 2x/day, Sinement > 25/100 3x/day, Pergolide(Permax) .25mg 2 of them 3x/day, and Amitriptylin > 25 mg 1x/day. I also take all the recommended vitamins, minerals, > antioxidants and DHEA. > > In the past I have gone a full day with no change in my symptoms, but the > symptoms weren't that bad. About a week ago I started taking 4 of the > Sinements and 8 of the Pergolides instead of 3 and 6. No change. I > started taking the meds between meals instead of at them. No change. Is > there anything else I can do or suggest to my neuro tomorrow??. I just > never get any relief. I have been tempted to stop taking everything again > to see what happens, but I am afraid I will get the same result as last > time > > Thanks in advance for any suggestions - or comments.