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BRIAN,IDA,AND OTHERS I have been so tied up in other matters in recent weeks that I have been unable to join in the latest spate of postings. I need to apologize to Brian as I had promised to send you information on my medication schedule. I had in fact completed a number of record sheets but found real difficulty in doing so because of the problems of clearly determining my position on the -2 to +2 scale which is mainly because I only experience symptoms when I am standing up and have been moving around for some little while.Something like driving a car I can do all day without even taking any medication and the only clear way I can know if I am in the 0 'on' state is to be sure that my left arm is swinging properly and that I am not limping and dragging my left leg which can only be determined after about five minutes of walking if I have been sitting down or standing up but not actually walking about to any extent.Also my position on the dyskinesia scale is difficult sometimes to determine unless I am actually active. However after a lot of experimenting with all sorts of schedules and doses I am sure that in my case the dyskinesia only comes to a small extent at the beginning of a dose of sinemet and almost always at the end WHATEVER THE SIZE OF THE DOSE.I have tried SinemetCR 25.100 one tablet at intervals from 2 to 4 hours - ok if there is sufficient overlapping but quite difficult to achieve in practice.CR 25.100 taking two tablets every 4 to 5 hours again the overlapping problem.Sinemet Plus 25.100 - quarter of a tablet every hour but this takes up to three hours to build up to give any effective relief and tends to produce a strange sort of intermittent dyskinesia. One third of the same tablet every hour produces a slightly better result.But here is the interesting thing on one occasion treating myself as a guinea pig I took one whole sinemetplus 25.100 tablet every hour for ten hours and the dyskinesia only started an hour or so after the end of the regime and more recently two 25.100 tablets every hour for 12 hours and again the dyskinesia not significantly unpleasant again came at end of dose. In both cases the higher doses produced a lot of energy and acted as an aphrodisiac. In addition to Seleginin 10mg I also take Permax 1mg a day and have tried more with no obvious benefit. These experiments with high and low sinemet inputs lead me to believe that end of dose dyskinesia is not just a simple matter of over dosing.Brian suggest that overdosing may have shot one into the 'twighlight zone'. It seems to me that that for people who suffer from end of dose there is a sort of very sensitive 'subliminal' zone on the way up to the fully dosed zone where problems occur with too low concentations of dopamine.If on starting your routine you are taking not enough sinemet you will climb too slowly through this subliminal zone and suffer start of dose dyskinesia but taking enough you will sail through it quickly and provided you keep above it you will be ok until some time after your last dose which is not too bad depending on the rate you descend back through the subliminal level.Best if this is when you are not going to be very active.In practice this is not very easy to achieve and it comes back to my original gripe several months ago that one ends up taking increased doses of sinemet not to deal with more severe pd symptoms but to deal with the dyskinesic effects of sinemet at the subliminal level. I would still prefer to use as little sinemet as possible and because of these effects I only really take it when I need it. For instance I usually go without medication until mid morning or when I am sedentary for long periods like driving a car or sitting at this screen. I'm very pleased Ida to hear that your own experience seems to tie in with this and that the new more flexible regime you adopted seems to have produced a lot of relief.I know many people think that you should not play about with times and doses. I have a rather self opiniated cousin who is a pharmacist and who is always preaching to me that the most important thing about medicine is to take the prescribed dose at the same time every day--good advice for a lot of medicines no doubt but one wonders how many PD sufferers are caught in this trap- not too many hopefully on this list but they should ask there doctors first.I wonder also whether some people suffer from diphasic and don't recognize it thinking it a normal part of PD and not drug caused! All the best David 68/4