Farley:
I am repeating this information per your inquiry -
From: Stephan Schwartz
To: SMTP("[log in to unmask]")
Date: 5/28/97 12:33pm
Subject: tolcapone (tasmar) -Reply
>>> W.S. <[log in to unmask]> 05/28/97
11:26am >>>
Has anyone heard or know anything about a new drug to
come out this year TOLCAPONE brand name (TASMAR) it
is a dopamine agonist I read about in prevention mag. ?
WHITIE
Hi Whitie:
TOLCAPONE is a Cathechol-O-Methyl Transferase (COMT)
inhibitor which prolongs the action of levodopa medicine in
the brain by inhibiting the action of the enzyme COMT in the
brain, which metabolizes dopamine.
It is manufactured by Hoffman-LaRoche Labs under the
brand name Tasmar# and is currently under clinical trials.
Side effects are reported as mild headache, nausea, loose
stool, and some transient dyskinesia. The drug acts to
maintain the blood levels of levodopa for a longer period
which should allow better control of symptoms with lower
dosages of medication.
Stephan 52/6
