> Has anyone heard or know anything about a new drug to > come out this year TOLCAPONE brand name (TASMAR) it > is a dopamine agonist I read about in prevention mag. ? > WHITIE > > Hi Whitie: > TOLCAPONE is a Cathechol-O-Methyl Transferase (COMT) > inhibitor which prolongs the action of levodopa medicine in > the brain by inhibiting the action of the enzyme COMT in the > brain, which metabolizes dopamine. > It is manufactured by Hoffman-LaRoche Labs under the > brand name Tasmar# and is currently under clinical trials. > Side effects are reported as mild headache, nausea, loose > stool, and some transient dyskinesia. The drug acts to > maintain the blood levels of levodopa for a longer period > which should allow better control of symptoms with lower > dosages of medication. > > Stephan 52/6 According to the FDA (CDER) web page Tolocapone was approved on June 5. Approvable Original New Drug Applications Original Application #: 020697 Approvable Date: 05-JUN-97 Trade Name: TASMAR Dosage Form: TABLET Applicant: HOFFMANN LA ROCHE INC Active Ingredient(s): TOLCAPONE OTC/RX Status: RX Charlie -- ********************************************************** CHARLES T. MEYER, M.D. MADISON, WISCONSIN **********************************************************