>Roche and Novartis compete in Parkinson's > >Roche has fired the opening shots in what looks likely to be a direct >battle between two new Parkinson's >disease therapies from Roche and Orion/Novartis. > >At a Roche symposium during the 7th International Symposium on Parkinson's >Disease, in London on March >23rd-26th, the company claimed superiority of tolcapone over Orion's >entacapone (to be co- marketed with >Novartis). > >Tolcapone and entacapone are the first of a new class of drugs for >Parkinson's, which inhibit the enzyme, >catechol-O-methyltransferase (COMT), found in serum and the brain. COMT >degrades both dopamine and its >precursor, levodopa, which is the current mainstay of treatment for >Parkinson's. COMT inhibitors increase brain >dopamine levels, making them potential adjunct therapies to levodopa. >Patients who have been taking levodopa >for several years generally start to experience sharp fluctuations in motor >ability. COMT inhibitors improve >symptom control in such patients, and allow the levodopa dose to be reduced. > >Tolcapone seems likely to be the first to market, as it was approved in >Switzerland (as Tasmar) in February for >fluctuating and non- fluctuating Parkinson's. Roche told Scrip the CPMP had >given it a positive opinion >(presumably at its March meeting - Ed; Scrip No 2219 /20, p 4) and is >aiming for a European launch sometime >this year. In the US, the company says it is "in the process of filing". > >Orion has completed Phase III trials with entacapone, but would not comment >on when it expects to file for >approval. Novartis has joint marketing rights in most European countries >(except for Scandinavia and the Baltic >Republics) and sole marketing rights in the US (Scrip No 2108, p 7). > >Clinical data >Placebo-controlled studies have shown similar clinical efficacy for >tolcapone 100mg or 200mg three times daily, >and entacapone 200mg four to ten times daily (with each levodopa dose), but >the two drugs have not been >directly compared. Tolcapone has the advantage of a less frequent dosing >schedule, although it was noted that the >higher entacapone dose frequency would presumably not greatly inconvenience >patients as it is merely added to >each levodopa dose, and levodopa itself is often taken several times a day. > >The companies presented clinical data at the recent Parkinson's meeting. >Both drugs allowed reductions in >levodopa dosage, and caused improvements in on/off time ("on time" is when >symptoms are under control; "off >time" results in dyskinesias and immobility) and in the United Parkinson's >Disease Rating Scale. One of Roche's >trials showed an increase in "on time" of about 25% with tolcapone 200mg >tid; studies also suggest an >improvement in quality of life for non- fluctuating patients. In one of >Orion's studies, patients on entacapone >200mg four to ten times daily experienced a mean increase in daily "on >time" from 9.3 hours to 10.7 hours >(+15%). (Other results with entacapone were reported in Scrip No 2140, p 23.). > >At the symposium, Roche devoted a session to comparing pharmacokinetic and >pharmacodynamic data for both >drugs, highlighting tolcapone's higher efficacy per unit dose and longer >half-life. The company claimed that, >"based on the available data, tolcapone appears to be a more potent COMT >inhibitor than entacapone at equal >doses". It also noted that while both drugs inhibit peripheral COMT, only >tolcapone seems to affect central >COMT. > >Orion rejected these claims, saying that pharmacokinetic data were less >relevant than clinical trials showing >similar efficacy for both drugs. The company also suggested to Scrip that >tolcapone's central effects may have >"safety implications". > >Some delegates thought it erroneous to draw conclusions about the relative >efficacies before direct comparative >studies have been performed. "Head-to-head trials are needed before any >claims can be made, " said Dr Mark >Guttmann of the University of Toronto, who has had experience with both >drugs. He thinks that ultimately the >market leader may be determined by issues such as cost and availability. > >Source: Scrip. 9th April 1997. > >Tolcapone is licensed in Switzerland. > > >