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Hi Folks, I saw the first posts come in on grapefruit interactions. However, it is not a subject I have studied as I never eat grapefruit or drink grapefruit juice because it does not go with my sweet tooth. For 3 days now I have had real problems with my meds (Sinemet & Requip). The meds have simply not worked at all in the morning and early afternoon or, have had a really long delay before switching on. This has been of some concern and ruined the best part of the week. I checked and double checked my diary of food eaten and timings of meds but could see nothing obvious to account for it - especially as the breakfast tends to be a standard "muesli with 2 slices of toast and marmalade. Then it hit me! On a total whim, whilst shopping, I had selected a grapefruit marmalade as a change - I don't think I had eaten grapefruit marmalade for 20 years previous to that. Well, for the last 3 days I had been eating grapefruit marmalade for breakfast. This morning I resumed my normal ORANGE marmalade. Result, back to normal on meds. Could half a pot of grapefruit marmalade over 3 days make that difference? Mary Manfredi's post showing grapefruit interferring with caffeine may be a further clue. As I have mentioned before, my neurologist advised coffee and tea being good for my PD symptoms (rigidity - not tremor) because they were a stimulant. I have been grateful for this advice because it does indeed seem to work for me. However, if the grapefruit blocked it..? Certainly because of the caffeine blocking alone, I would now avoid grapefruit. I believe that, where symptoms or response to medications vary in the short term, there is always a reason but it can be difficult to find. Thanks Mary and others for bring this up - Julia is finishing the grapefruit marmalade. Ernie Peters <[log in to unmask]>