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Someone, I believe it may have been Ivan, responded to my request for help figuring out why my meds don't seem to work as well as they do for other PWP. The response said to take the Sinement 30-45 minutes before eating, and to limit protein until supper. It seems to be helping!! I'm still going to try to switch to a PD specialist, but in the meantime, does anyone have an opinion on how much protein, in grams, is too much before evening? And also, what about the other meds - permax (pergolide), eldypryl (selegiline) and amantadine - take 'em with the sinement or with the meals? Thanks Bruce A. 51 / 2.5