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Bob, I'm new to this list, but not to PD. 50/12 I really think Ernie Peters advice is right. Of the items mentioned STRESS is the most important. I know we all have it What really helps me is to change my environment. I live in Florida but I leave for Wisconsin in two weeks Also, did you change your diet? You are on the same dose I am on minus the Eldepryl, I felt much better when iwent off eldepryl (nasty stuff) You guys in the U K have all the latest drugs available to you, forget the pallidotomy. Lastly God Bless.