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Brian, Most of what I've read claims that Sinemet is felt almost immediately (within a few days, perhaps?). Others on the list have told me that it took them awhile to feel the benefits. My mother (Joyce, 67/5 months) started with Sinemet 25/100 3x/day (or was it 4??). She did not feel much of anything for a long time (a month or so). The doctor then slowly had her add Permax and she began to notice a change. Unfortunately, she didn't feel back to normal when on the combination, but she did notice when she needed to take the next dose. Also, some days are better than others. I would definitely bring it up with your doctor — perhaps a different combination would work better for you. Good luck and good health. Debbie White [log in to unmask] > I just started taking Carbidopa/Levodpa 25/100, 3 times a day and > Selegiline(Eldepryl) 5mg twice a day on Wednesday, June 25. So far I have > not really noticed any change or improvement. I was wondering how long > others have been taking this medication before noticing any change or > improvement. > Brian Carlson