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Hello all list members! I was quite comfortable with the Oxidative Stress Hypothesis as the most popular model to explain PD pathogenesis and progression. But now with last week's announcement about alpha synuclein I am quite lost. Does anyone have any thoughts about how the two might be linked (ie. the idea of how alpha synclein might clump lead to free radical formation via GSH, iron etc.)? Does last week's announcement blow the oxidative stress hypothesis right out of the water? Natalie Kontakos [log in to unmask]