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Dear Brian, Something in this discussion I don't understand. Why is it, Brian, that you so strongly resist the idea that our nervous systems don't all react the same way. Your model is usefull for you and many others, but it can not explain everything about med's and parkinson. The med's scheme I now use gives one unescapable, but foreseeable period of dyskinesia that starts about 4 hours after I have taken my last sinemet CR of the day. It lasts about 1 hour. Trying to explain this, one needs a model in which a too low dose of sinemet activates certain structures, which activation is overruled by another system, which uses a higher dose. This however is pure hypothetical, the effects themselves are not and can not be dismissed because we can't explain them. I want to mention yet another phenomenon. From the start of my PD I suffered from cramps in my right feet every morning after getting up (I use no med's at all at night). I was amazed about that because in the beginning my parkinson has been exclusively on my left side. Now that I use my new med's scheme this symptom has nearly disappeared. This is completely unexplainable for me, but yet it's true. Ida Kamphuis, 53/12+ Holland