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Charles, I have checked with two doctors and two herbalists. They all said that many people take SJW with either Paxil or Prozac in order to be able to cut down on the drug without losing the anti-depressant. I appreciate your concern Charles. I am glad I have friends who watch out for me. I am also very conscience of drug interactions since I have been victim of some of them. don't forget how to laugh Marling