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Brian, I share your opinion that we as individuals must take responsibility for our medications. I also share your experience in regard to the narrow window between overdose and underdose of levadopa. The problem is exacerbated here in Australia as Madopar is only available in capsule form, with the smallest dose being 50:12.5. The smallest Sinemet tablet is 100:25. This can be divided in 1/2 (back to 50:12.5) but not quarters. In my case, a single sinemet (100:25), taken 3 hourly, fails to 'turn me "On"' at all, whereas 1 and1/2 sinemet 3 hourly (effectively 150:37.5) produces a mild right side dyskinesia (I recently had a right sided pallidotomy) . I feel certain that were I able to put myself on 1 and 1/4 tablets, I would be able to reproduce at will (brave words, I know) the perfect "on" that even now I experience several times a week. Sinemet CR is only available here as 200:50. I have found it impossible to work with, as I have either no "on", or an intolorable level of right sided dyskinesia. When I have raised this subject with neurologists, they have without fail assured me that 50:12.5 is a "tiny" amount, which should not need reducing. It seems that there is "something wrong with me" if I find otherwise. Doctors are just like the rest of us, they prefere it if things fall into neat catagories. I don't blame them for this, but I make sure I remember it in all my dealings with them. Dennis. ++++++++++++++++++++ Dennis Greene 47/10 [log in to unmask] ++++++++++++++++++++