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Bruce, I am glad that now you are taking your Sinemet before food you are doing better. This "food-Sinemet timing" comes up frequently but is always worth emphasising for the benefit of new list members. It is also worth emphasising for people who have been succesfully taking Sinemet with food for some time and suddenly run into increased symptom problems. Many, including myself at the time, don't immediately realise that the "food reduced" amount of l-dopa is no longer sufficient for their needs. Remember, falling even a little below the Sinemet requirement, can have quite a large effect on the PD. Most people will find that there will come a time when they can no longer waste a large portion of the l-dopa availability by taking it with food. Those who are having no trouble taking Sinemet with food, simply have a lower requirement and can afford to waste a little. Also, do not fall into the trap of believing that ONLY protein interferes with Sinemet. My neurologist told me ALL food interferes with Sinemet and I have found this to be the case. In other words, all the advice of saving protein for evening meals is good advice BUT, don't fall into the trap of thinking, "It is a low protein meal, it will not affect at all.". The important thing, is to give the Sinemet a good start of 30mins to an hour (40-45 mins works best for me). As a matter of fact, I have found that if the Sinemet gets a really GOOD start, even quite large amounts of protein do not interfere too much for me. Good luck, Ernie. 54/3.7 At 22:41 05/07/97 -0400, you wrote: >Brian Collins, > >I just recently switched my intake of Sinement to 30-60 minutes before >meals and minimal protein until supper, as was suggested by a number of >folks on this List and it definitely seems to help my bradykensia. (And I >also found a Movement Disorder specialist who presumably would have >mentioned this to me sooner - since my current neurologist had no clue - >and since I hadn't been paying attention here! Couldn't get an appt until >Sept 8 though, but I don't feel quite as desperate now so that doesn't >matter.) > >I haven't quite figured out yet when it's best to take the Permax, however. > So I take it with the meals. > >Bruce Anderson (51/2.5) Ernie Peters <[log in to unmask]>