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currently I take one 10/100 kick starter in the AM followed by one 25/100 CR, one eldepryl and 1 mg permax and one artane an hour and half later; four hours later I repeat one 25/100 CR, one eldepryl, and 1 mg permax; 3 -4 hours later I repeat all (except the eldepryl). My problem is I have (over the last 3 weeks) had a sudden increase in off time. I can't get out of a chair, have extreme bradykinesia, extreme stiffness and tremor. I don't have any dyskinesia. I have been on this regimen for approx. 4 years. I will be calling my neuro this week, I just would appreciate any thoughts you fellow PDers may have. I am also giving SERIOUS thought to a pallidotomy, if my insurance will cover some of it. Thank you for your advice. Bob 46/5 (had symptoms long before diagnosis)