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>Dear Pat, Donna, Rosemary, Robert and David > > > >David L, you are the one who started this thread. I can agree with >your observation that the wearing off dyskinesia is not influenced >by the amount of drugs taken, moreover it may be that the end of dose >dyskinesia is less with a higher dose. The problem >for me however is, that I have a diminished therapeutic window on top of >the mentioned symptoms. So when I take too much sinemet I can expect top >of dose dysk. Your Parkinson, David, is not as much advanced as mine is. Thankyou Ida you are right.I noticed the effect very soon after I started using sinemet albeit in very minor form.Like your however I believe that this diphasic stuff is a very real experience effecting a minority of pd ers. Sorry that you have backed out of the great debate progressing at "snail pace". My curiosity having been thoroughly arouses as to the cause I expect to continue it at snail pace temporallly blipped by a snail pace house moving operation. Look forward to a another exciting installment when I have fathomed out how it is possible for an ordinary pd er to reproduce end of dose dyskers. David Langridge.