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Donna, I don't have a solution to your problem, but I can tell you you're not alone. I, too, have been diagnosed for 11 years and am having annoying on/off fluctuations. I'm so uncomfortable when I'm "off" that I can't wait to get "on," but the dyskinesias are so debilitating that I welcome some "off" time for relief. And so passes the day. Something you might try is a different compound - the 25/100 CR's instead of the higher dosage. I take them, but because the dosage is less I have to take more ( 10 per day ), so I haven't really accomplished anything. What seems more promising are the two new medications - pramipexole and tolcapone - which should allow us to cut down on the amount of sinemet we take. If you come up with any great solutions, let me know. Pat