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Someone ( I have lost the actual message) recently asked a question concerning substitution of Permax for Sinemet as a means of combatting dyskinesia. Margaret did this some years ago as part of a clinical trial supervised by her neurologist. She was troubled by Sinemet-induced dyskinesia and at the time hadn't been able to tolerate a total daily dose of more than three 100/25 mg tablets daily. Beginning with the smallest Permax, over a period of a couple of months she built up to a daily intake of three mg. Previously she had been taking three 5 mg doses of Parlously and this was stopped during the trial. During this time her Sinemet was cut back, but she was unable to stop taking it altogether. This was because she found that Permax was not a completely adequate substitute and she needed at least half a 100/25 tablet three times a day. At this dosage, there was less dyskinesia, but there was also a lot less movement, and finally we tried increasing the Permax to 5 mg a day. This more or less restored the movement to an acceptable level but of course the dyskinesia again became troubling. In addition, there were signs that Margaret would not be able to long tolerate such a high dosage. She was becoming somnolent and withdrawn and the trial was discontinued. We have tried liquid Sinemet and Clozaril but these afforded only partial relief and Margaret still wasn't able to tolerate as much Sinemet as she needed until she had her pallidotomy three months ago. Take Care, Mark (CG for Margaret, 65/28 yrs) ~~~~~~~~~~~~~ Mark Atyeo. 61 6 286 2606 I always said I wanted to be somebody, I just wish I'd been more specific