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Janet, Thank you for an interesting thought. I will begin to take note of sinemet effects during my cycle also. Maybe if enough of us do this we can come up with some answers through the list. Gee Wizz, using the list to do research on PD?? just because we have such a good sample group?? from such a variety of places around the world?? Who woulda thought that might happen?? don't forget how to laugh Marling