Dear Ida, Pat, Donna, Marty, Robert and David Thanks for reply Ida - I do not say much on the list but can assure you I have a file folder full of converstion re diphasic dyskinesia from the past year. I have decided in my unscientific way that everyones med sch is individual - thats what makes this dyskinesia so frustrating. Ida, my doctor is a PD specialist (same one as the Schwindlers) at KU med center - I like him very much -he agrees about the end of dose dys but I also have peak dose at times. He asked me if I wanted to go into a drug study for tolcapone and that is why I am taking Permax. Half of us were randomized to permax and the other half to tolcapone - and I got Permax. I will be able to try the tolcapone after 12 weeks. I can't really tell about the permax - haven't found the right balance with sinemet. Lately my upper arms especially ache constantly -is that dystonia - I attributed it to rigidity trying to stop the dyskinesia. I know stress affects dys but now wonder about cafeine. Don't know if any of this makes sense but keep your messages coming. They help. Rosemary ***************************************************** Rosemary Paul [log in to unmask] Community Services x3919 *****************************************************