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Brian, This is the last time I write to you about my dyskinesie and old or new or changed med. schemes. You are right being irritated about my not keeping my promise to send you a second list with data. I did send you the first one. Your reaction on that, did give me the paralyzing feeling that all the mails I had written, trying to explain what I meant by saying my reaction on the med's were of the dyphasic and wearing off dyskinesia kind, had bounced against a concrete wall of polite disbelief. I know that does not excuse my stopping to react but is at best only an explanation. So for me, I do close the discussion. All things I can say about it are said far more than once. I regret it happened like it did. Because you say you missed my change of schedule,I repeat them once. So here we go: 8 o clock :1 sin. CR 25/100, eldepryl 5, 1/2 permax 0.25, orphenadrine 11. ,, 1/2 sin. CR 25/100, eldepryl 5, 1/2 permax 0.25, orphenadrine 14. ,, 1/2 sin. CR 25/100 1/2 permax 0.25, orphenadrine 17. ,, 1/2 sin. CR 25/100 1/2 permax 0.25, orphenadrine 20. ,, 1/2 sin. CR 25/100 1/2 permax 0.25, orphenadrine This scheme caused about 7 hours of heavy dyskinesia, which started about 3.5 hour after taking sinemetCR and lasted till a bit more than an hour after taking the next. I only changed the sin.CR schedule, taking 1 sin.CR 25\100 at 11.00, at 14.30, and at 18.00. This scheme causes one hour of heavy dyskinesia, which starts somewere between 10 and 11 at night and a very short time of dyskinesia(to be counted in minutes) about an hour after the first sinemet. And of course more time "off" in the morning. Regards, Ida Kamphuis, 53/12+ , Holland